| 沈毅,陶可,丁小军,窦红静,李军,孙康,孙坚.葡聚糖包裹的超顺磁性Fe3O4纳米颗粒用于MRI造影剂的研究[J].口腔材料器械杂志,2012,21(1):22-27. |
| 葡聚糖包裹的超顺磁性Fe3O4纳米颗粒用于MRI造影剂的研究 |
| Study of dextran-coated superparamagnetic iron oxides nanoparticles as constrast agent |
| 投稿时间：2011-11-15 修订日期：2011-12-14 |
| DOI：10.11752/j.kqcl.2012.01.05 |
| 中文关键词: 界面共沉淀法 葡聚糖 超顺磁性Fe3O4纳米颗粒 间质注射 MRI造影剂 核磁共振波谱分析 |
| 英文关键词:Interfacial coprecipitation Dextran Superparamagnetic iron oxides nanoparticles Interstitial injection MRI constrast agent Nuclear magnetic resonance spectroscopy |
| 基金项目:上海市科学技术委员会资助项目(08DZ2271100) |
| 作者 | 单位 | E-mail | | 沈毅 | 上海交通大学医学院附属第九人民医院·
上海交通大学口腔医学院口腔颌面外科, 上海市口腔医学重点实验室, 上海 200011 | | | 陶可 | 上海交通大学材料科学与工程学院, 上海 200240 | | | 丁小军 | 复旦大学附属中山医院口腔科, 上海 200032 | | | 窦红静 | 上海交通大学材料科学与工程学院, 上海 200240 | | | 李军 | 上海交通大学医学院附属第九人民医院·
上海交通大学口腔医学院口腔颌面外科, 上海市口腔医学重点实验室, 上海 200011 | | | 孙康 | 上海交通大学材料科学与工程学院, 上海 200240 | ksun@sjtu.edu.cn | | 孙坚 | 上海交通大学医学院附属第九人民医院·
上海交通大学口腔医学院口腔颌面外科, 上海市口腔医学重点实验室, 上海 200011 | jianjian60@yahoo.com |
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| 中文摘要: |
| 目的: 探讨葡聚糖包裹的超顺磁性Fe3O4纳米颗粒（dextran-coated superparamagnetic iron oxides nanoparticles,dextrarr/SPlONP）作为间质注射的MRI造影剂的可行性。方法: 应用界面共沉淀法,制备dextran/SPIONP,用透射电镜、能谱分析、X射线衍射、红外光谱测试、热重分析等方法对dextran/SPlONP的大小、磁性能等进行表征,并研究葡聚糖对SPlONP的影响。然后,将dextran/SPIONP稀释成不同剂量,兔舌粘膜下问质注射后的不同时间段,切取前哨淋巴结,行核磁共振波谱分析,确定dextran/SPIONP的最适剂量和最佳检测时间。结果: dextran/SPION的平均直径为6～9nm,其表征与经典的共沉淀法制备的颗粒一致,具有超顺磁性,葡聚糖是影响SPIONP饱和磁化强度的主要因素。dextran/SPIONP用于间质注射的最适剂量为含铁量20μmol,最佳检测时间为注射后24h。结论: 用界面共沉淀法制备的dextran/SPIONP是一种适用于间质注射的MRI造影剂。 |
| 英文摘要: |
| Objective: To study the possibility of using dextran-coated superparamagnetic iron oxides nanoparticles(dextran/SPIONP)prepared by interfacial coprecipitation as a MRI constrasi agent for interstitial injection. Methods: Dextran/SPIONP was prepared interfacial coprecipitation. Dextran/SPIONP was characterized by transmission electron microscopy,spectrum analysis, X-ray diffraction, infrared spectrum, and thermal gravitational analysis. The effect of dextran for SPIONP wasstudied. Dextran/SPIONP was administrated into the tongue submucosa of a rabbit by interstitial injection after being diluted fordifferent doses. Sentinel lymph nodes in different stages were harvested to determine the best dose and imaging timing of Dextran/SPIONP by nuclear magnetic resonance spectroscopy. Results: Average diameters of dextran/SPIONP prepared by interfacial coprecipitation were from 6 to 9nm. Its characteristics with superparamagnetism are in accordance with those by classic coprecipitation, Dextran is the main factor to influence saturation magnetization of SPIONP. The best dose and imaging timing ofdextran/SPIONP for interstitial inject were 20pmo1 of iron and 24 hours after administration, respectively. Conclusions: dextran/SPIONP prepared场interfacial coprecipitation is a MRl constrast agent for interstitial injection. |
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