| 叶琦,石新莹,曹姗姗,赵克,张新平.多孔钛孔隙率和孔隙尺寸对其力学性能及细胞相容性的影响[J].口腔材料器械杂志,2013,22(1):7-12. |
| 多孔钛孔隙率和孔隙尺寸对其力学性能及细胞相容性的影响 |
| Influence of porosity and pore size on mechanical properties and cytocompatibilityof porous titianium |
| 投稿时间：2012-11-02 修订日期：2012-11-22 |
| DOI：10.11752/j.kqcl.2013.01.02 |
| 中文关键词: 多孔钛 孔隙率 孔隙尺寸 力学性能 细胞黏附 细胞增殖 |
| 英文关键词:Porous titanium Porosity Pore size Mechanical property Cell adhesion Cell proliferation |
| 基金项目:国家自然科学基金(50871039); 广东省自然科学基金(10151064101000017) |
|
| 摘要点击次数: 864 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：研究多孔钛孔隙率和孔隙尺寸对其力学性能及细胞黏附与增殖的影响,为临床应用提供依据。方法：调整加入造孔剂的粒径及质量分数,粉末冶金法制备12组不同孔隙结构的多孔钛,金相显微镜观察其孔隙特征,计算孔隙率及平均孔隙尺寸。万能材料试验机测定其屈服强度、弹性模量及弯曲强度。筛选力学参数与人皮质骨匹配的多孔钛,CCK-8法测定其MC3T3-E1细胞黏附及增殖活性。结果：随着多孔钛孔隙率增大,其屈服强度由406.0 MPa降至52.9 MPa,弹性模量由18.2 GPa降至3.5 GPa,弯曲强度从327.2 MPa降至50.6 MPa。多孔钛孔隙率和孔隙尺寸对其屈服强度、弹性模量及弯曲强度均有影响(P<0.05)。MC3T3-E1细胞在多孔钛表面的早期黏附吸光度值低于致密纯钛和塑料培养板对照组(P<0.05),但细胞在前者的增殖活性显著高于后者(P<0.05)。结论：在本实验研究范围内,当孔隙率为43.1%～53.3%、且孔隙尺寸为154.8～191.6μm时,多孔钛的力学性能与人骨接近,且有利于成骨细胞增殖。 |
| 英文摘要: |
| Objective: To evaluate the influence of porosity and pore size on mechanical properties,cell adhesion and proliferation rates of porous titanium,thus to provide theoretieal basis for the clinical application in orthopaedic and dental fields. Methods: Twelve groups of porous titanium samples with different porosity ratios and pore sizes were fabricated by powder metallurgy process. A metallographic microscope was used to analyze the microstructural surface characteristics and pore morphology. The compressive yield strength,Young's modulus and bending strength of porous titanium samples were assessed by Universal testing machine. Then six groups of porous Ti samples were selected for further MC3T3-EI cell adhesion and proliferation tests. Results: The porous Ti samples exhibit three-dimensionally intercon nected permeable and open structures. With increasing porosity,the yield strength and Young's modulus of porous Ti gradually decrease from 406.0 to 52.9 MPa,and from 18.2 to 3.5 GPa,respectively. Similarly,the bending strength is between 327.2 and 50.6 Mpa. Clearly,both porosity and pore size have effects on the yield strength,Young's modulus and bending strength of porous titanium (P<0.05). Cytocompatibility Results show that MC3T3-EI cells were better attached and proliferated on both surfaces of dense Ti and polypropylene plate over the porous Ti. While the cell proliferation rate 15 higher on porous Ti than on other two types of samples. Conclusions: both porosity and pore size have significant influence on the compressive yield strength,Young's modulus and bending strength of porous titanium. Porous titanium samples with porosity in the range of 43.1%-53.3% and pore size from 154.8 to 191.6 μm possess not only similar mechanical properties to that of natural human bones,but also good cytocompatibility,which could meet the mechanical and biological requirements in orthopaedic and dental implant applications. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|