| 李君,梁刘凤,钟雯怡,刘琪.羊富血小板胶细胞基质在2种牙周缺损模型中的修复效果[J].口腔材料器械杂志,2016,25(4):204-208. |
| 羊富血小板胶细胞基质在2种牙周缺损模型中的修复效果 |
| Effects of goat platelet rich gel cell matrix on repairing two kinds of periodontal defect models |
| 投稿时间：2015-11-30 修订日期：2016-04-20 |
| DOI：10.11752/j.kqcl.2016.04.08 |
| 中文关键词: 富血小板胶-牙周膜成纤维细胞基质 牙周组织再生 牙周缺损 |
| 英文关键词:Platelet-rich gel-periodontal ligament fibroblast cell matrix Periodontal regeneration Periodontal defects |
| 基金项目:贵州省科技厅对外合作重点基金项目(编号：C-275) |
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| 中文摘要: |
| 目的 探讨羊富血小板胶-牙周膜成纤维细胞基质（PRgel-PDLFs）促进不同原因造成的牙周缺损再生的效果。方法 用新鲜全血制取富血小板血浆（PRP），并加入催化剂与成纤维细胞一起培养合成PRgel-PDLFs基质；然后将24只山羊随机分为急性牙周缺损组和慢性牙周炎缺损组，模型建成后所有动物一侧植入PRgel-PDLFs基质于牙周缺损区，另一侧为手术空白组，术后10周，进行CT影像学检查和组织学测量分析。结果 10周后CT影像学和组织学检查显示：两组均在牙根面见新生牙骨质样组织、牙周膜样组织和牙槽骨样组织，且PRgel-PDLFs组再生的牙周组织明显多于空白组（P<0.01）；急性缺损组和慢性牙周炎缺损组的组织再生量相近，差异没有统计学意义（P>0.05）。结论 PRgel-PDLFs基质能够促牙周组织再生，且对急性牙周缺损和慢性牙周炎造成的牙周缺损修复效果相近。 |
| 英文摘要: |
| Objective To investigate the effects of goat platelet-rich gel-periodontal ligament fibroblast cell matrix (PRgel-PDLFs) on periodontal regeneration of various periodontal defects. Methods Plateletrich plasma (PRP) was acquired from fresh blood using density gradient centrifugation technique. And then PRP and PDLFs was mixed cultured into PRP-gel. 24 healthy goats were randomly divided into acute periodontal defect group and chronic periodontal defect group; and one side of each model was treated with PRgel-PDLFs, the other side was used as blank control group. After 10 weeks, the defect area was examined by histological observation and CT analysis. Results New alveolar bone, cementus and periodontal ligament were observed on the root surfaces in both groups. Compare with the blank group, the extent of periodontal tissue regeneration was more prominent in the PRgel-PDLFs group, and there was obviously statistics significance (P<0.01). There was no obviously difference in periodontal tissue regeneration between acute periodontal defect group and chronic periodontal defect group (P>0.05). Conclusion PRgel-PDLFs could improve periodontal regeneration, and had similar effects on treating chronic periodontal defects and acute periodontal defects. |
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