| 牛建华,易敏,许卫星.3D打印技术制备β-TCP仿生骨支架的形态结构特点及其成骨性能分析[J].口腔材料器械杂志,2023,32(3):183-188. |
| 3D打印技术制备β-TCP仿生骨支架的形态结构特点及其成骨性能分析 |
| Prepared using 3D printing technology β- morphological and structural characteristics of TCP biomimetic bone scaffold and its osteogenic performance analysis |
| 投稿时间：2023-04-09 修订日期：2023-06-19 |
| DOI：10.11752/j.kqcl.2023.03.06 |
| 中文关键词: β-TCP 仿生骨支架 3D打印技术 骨修复 |
| 英文关键词:β-TCP Biomimetic bone scaffold 3D printing technology Bone repair |
| 基金项目:上海市黄浦区科委科技项目基金(编号:HKM201727) |
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| 中文摘要: |
| 目的 分析 3D 打印技术制备 β- 磷酸三钙(β-TCP) 仿生骨支架的形态结构特点及其成骨性能。方法 随机选取 24 只新西兰兔, 建立股骨髁部缺损模型。采用 3D 打印技术制备 β-TCP 仿生骨支架,将实验兔随机分为 2 组, 每组 12 只。其中对照组未植入任何材料; 实验组植入 β-TCP 仿生骨支架, 观察4 周、8 周和 12 周后的两组骨修复结果, 评价其成骨性能。结果 实验组术后第 4 周、8 周、12 周时的骨组织学评分均高于对照组, 骨小梁厚度、数目、骨小梁体积/总体积均高于对照组(P<0.05)。3D 打印的仿生骨支架的直径、高度、孔隙率以及抗压强度、弹性模量与天然松质骨之间的差异无统计学意义(P>0.05)。结论 3D 打印技术制备的 β-TCP 仿生骨支架, 可促进骨缺损的修复, 支架形态学结构及成骨性能与松质骨相近。 |
| 英文摘要: |
| Objective Our study analyzed the morphostructual characteristics and osteogenic properties of β-Tricalcium phosphate(β-TCP) biomimetic bone scaffold frbricated by 3D printing technology. Methods Randomly select 24 experimental white rabbits and establish models of femoral condylar bone defects. Prepared using 3D printing technology β- TCP biomimetic bone scaffold was randomly divided into 2 groups of 12 rabbits in each group. The control group was not implanted with any materials; Experimental group was implanted with β- TCP biomimetic bone scaffold. After 4, 8 and 12 weeks of observation, the bone repair results of the two groups were compared to evaluate the osteogenic performance. Results The bone histological scores of the experimental group were higher than those of the control group at weeks 4, 8, and 12 after surgery. The thickness, number, and volume/total volume of bone trabeculae in the experimental group were higher than those in the control group (P<0.05). The diameter, height, porosity, compressive strength, and elastic modulus of the 3D printed bone scaffolds had no significant differences with nature cancellous bone (P>0.05). Conclusions 3D printing technology preparation β- TCP biomimetic bone scaffold can promote the repair of bone defects, and its morphological structure and osteogenic performance are similar to those of cancellous bone. |
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