| 徐绅.基于广义估计方程评价正畸治疗对牙周病致前牙移位患者牙槽骨、CGRP水平及微环境改建的影响[J].口腔材料器械杂志,2024,33(3):158-165. |
| 基于广义估计方程评价正畸治疗对牙周病致前牙移位患者牙槽骨、CGRP水平及微环境改建的影响 |
| Evaluation of the effects of orthodontic treatment on alveolar bone, CGRP level and microenvironment remodeling in patients with anterior tooth displacement caused by periodontal disease based on generalized estimation equation |
| 投稿时间：2023-06-29 修订日期：2023-09-28 |
| DOI：10.11752/j.kqcl.2024.03.05 |
| 中文关键词: 广义估计方程 降钙素基因相关肽 前牙移位 口腔正畸 牙槽骨 微环境改建 |
| 英文关键词:Generalized estimation equation Calcitonin gene-related peptide Anterior teeth displacement Orthodontics Alveolar bone Remodeling of microenvironment |
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| 中文摘要: |
| 目的 探讨广义估计方程评价正畸治疗对牙周病致前牙移位患者牙槽骨、降钙素基因相关肽（CGRP）水平及微环境改建的影响。方法 选取 2019年 8月至 2022年 8月期间于我院就诊的牙周病致前牙移位患者286例，按照随机数字表法将患者分为对照组（n=143，采用牙周基础治疗）和观察组（n=143，采用口腔正畸治疗），比较两组患者的临床资料及治疗前后CGRP水平、前牙覆盖距离、牙周袋深度、牙槽骨高度、出血指数、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-2（IL-2）水平，并构建广义估计方程（GEE）分析患者正畸治疗后 CGRP水平与牙槽骨及微环境改建的关联；运用 Spearman分析 CGRP水平与前牙覆盖距离、牙周袋深度、牙槽骨高度、TNF-α、IL-6、IL-2水平的相关性。结果 与治疗前相比，两组牙周病致前牙移位患者治疗后30d和治疗后1年的CGRP水平上升、前牙覆盖距离缩小、牙周袋深度减小、牙槽骨高度减小、出血指数降低、炎症因子TNF-α、IL-6、IL-2分泌减少，且观察组前牙移位患者的以上指标明显优于对照组前牙移位患者（P＜0.05）。通过Spearman相关性分析发现，血清CGRP与前牙覆盖距离、牙周袋深度、牙槽骨高度、出血指数、TNF-α、IL-6、IL-2呈显著负相关（P＜0.05）。GEE分析结果显示，治疗后观察组的前牙覆盖距离、牙周袋的深度、牙槽骨的高度、出血的指数、TNF-α、IL-6、IL-2优于对照组，差异具有统计学意义（P＜0.05）。结论 CGRP水平与牙周病致前牙移位患者正畸治疗中牙槽骨及微环境改建的密切相关，可以依据CGRP水平与牙周病致前牙移位患者正畸治疗中牙槽骨及微环境改建的相关性判断出患者的治疗效果是否良好，在口腔治疗中起着重要作用。 |
| 英文摘要: |
| Objective To evaluate the effects of orthodontic treatment on alveolar bone, calcitonin generelated peptide (CGRP) levels and microenvironment remodeling in patients with anterior tooth displacement caused by periodontal disease by generalized estimation equation. Methods A total of 286 patients with anterior tooth displacement due to periodontal disease who were treated in the hospital from August 2019 to August 2022 were selected, and divided into the control group (n=143, receiving periodontal basic treatment) and the observation group (n=143, receiving orthodontic treatment) according to random number table method. Clinical data, CGRP level, anterior tooth covering distance, periodontal pocket depth, alveolar bone height, bleeding index, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-2 (IL-2) before and after treatment were compared between the two groups. Generalized estimation equation (GEE) was constructed to analyze the relationship between CGRP level and remodeling of alveolar bone and microenvironment after orthodontic treatment. The correlation between CGRP level and anterior tooth covering distance, periodontal pocket depth, alveolar bone height, TNF-α, IL-6 and IL-2 levels was analyzed using Spearman's method. Results Compared with the pre-treatment period, the patients with anterior tooth displacement caused by periodontal disease in the two groups showed an increase of CGRP level, anterior tooth covering reduced, periodontal pocket depth decreased, alveolar bone height decreased, bleeding index decreased, and secretion of inflammatory factors TNF- α, IL-6 and IL-2 decreased. The above indexes of patients with anterior tooth displacement in the observation group were significantly superior to those in the control group (P<0.05). Spearman correlation analysis showed that serum CGRP was significantly negatively correlated with anterior tooth coverage distance, periodontal pocket depth, alveolar bone height, bleeding index, TNF-α, IL-6, and IL-2 (P<0.05). GEE analysis results showed that the anterior tooth covering distance, periodontal pocket depth, alveolar bone height, bleeding index, TNF- α, IL-6 and IL-2 in the observation group were superior to those in the control group after treatment, and the difference was statistically significant (P<0.05). Conclusion The level of CGRP is closely correlated with the remodeling of alveolar bone and microenvironment in patients with periodontal disease-induced anterior tooth displacement during orthodontic treatment. It is possible to evaluate the treatment effect of patients based on the correlation between CGRP levels, and the alveolar bone and microenvironmental modification in orthodontic treatment of patients with anterior tooth displacement caused by periodontal disease, and plays an important role in dental treatment. |
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