| 张晋分,李娜.正畸压膜保持器表面抗菌涂层的制备及其抗菌性研究[J].口腔材料器械杂志,2025,34(2):78-84. |
| 正畸压膜保持器表面抗菌涂层的制备及其抗菌性研究 |
| Preparation and antibacterial study of antimicrobial coating on the surface of orthodontic retainer |
| 投稿时间：2024-06-11 修订日期：2024-11-22 |
| DOI：10.11752/j.kqcl.2025.02.03 |
| 中文关键词: 保持器 抗菌 涂层 聚乳酸-氯己定 氯己定 |
| 英文关键词:Retainer Antibacterial Coating PDLLA-CHX Chlorhexidine |
| 基金项目: |
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| 摘要点击次数: 11 |
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| 中文摘要: |
| 目的 通过在正畸压膜表面构建外消旋聚乳酸-氯己定（PDLLA-CHX）抗菌涂层，探讨其材料学特性及抗菌性能。方法 将正畸压膜片浸泡于含氯己定的聚乳酸-乙酸乙酯溶液中，以液相沉积法形成抗菌涂层。采用硬度仪测试涂层硬度，利用扫描电子显微镜（SEM）观察涂层的表面形态，运用X射线电子能谱（XPS）分析涂层的表面元素组成。开展了抑菌环实验和平板涂布实验，评估涂层的抗菌性能。结果 硬度测试显示涂层并未显著影响正畸压膜的硬度，仍保持在中等硬度塑料的参考值范围内。SEM观察结果显示涂层表面形成了致密的孔隙结构，XPS结果表明涂层中接枝了氯己定元素，由此证明成功制备了PDLLACHX抗菌涂层；抑菌环实验结果显示，接枝的样品形成了显著的抑菌环，而未接枝的样品无此现象；平板涂布实验进一步证实了涂层的抗菌效果。结论 通过液相沉积法成功在正畸压膜保持器表面构建了PDLLACHX抗菌涂层，体外实验验证了其优异的抗菌性能。该研究为预防因佩戴正畸压膜保持器引起的口腔感染提供了新的策略和方法。 |
| 英文摘要: |
| Objective To construct an antibacterial coating composed of poly(DL-lactic acid)-chlorhexidine (PDLLA-CHX) on the surface of orthodontic thermoplastic retainers and investigate its material properties and antibacterial performance. Methods Orthodontic retainer films were immersed in a solution of PDLLA and chlorhexidine dissolved in ethyl acetate, forming the antibacterial coating via a liquid-phase deposition method. A hardness tester was used to assess the surface hardness of the coated samples. Scanning electron microscopy (SEM) was employed to observe the surface morphology, while X-ray photoelectron spectroscopy (XPS) was used to analyze the elemental composition of the coating. The antibacterial activity of the coating was evaluated using inhibition zone assays and plate coating tests. Results Hardness testing indicated that the PDLLA-CHX coating did not significantly alter the hardness of the retainer material, maintaining values within the reference range for medium-hard plastics. SEM observations revealed a dense, porous surface structure, confirming successful coating formation. XPS analysis demonstrated the successful grafting of chlorhexidine into the coating. Inhibition zone assays showed that coated samples produced distinct antibacterial zones, whereas uncoated controls did not. The plate coating test further validated the antibacterial efficacy of the coating. Conclusion A PDLLA-CHX antibacterial coating was successfully fabricated on the surface of orthodontic thermoplastic retainers via liquid-phase deposition. In vitro experiments confirmed its excellent antibacterial properties. This study offers a novel strategy for preventing oral infections associated with the use of orthodontic retainers. |
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