| 王卫东,袁小鹏,吴静洁.复发性口腔溃疡患儿血清可溶性B7-H3和干扰素调节因子5水平的变化及其与复发的关系[J].口腔材料器械杂志,2025,34(3):159-163,173. |
| 复发性口腔溃疡患儿血清可溶性B7-H3和干扰素调节因子5水平的变化及其与复发的关系 |
| The change of serum soluble B7-H3 and interferon regulatory factor 5 levels in children with recurrent oral ulcers and their association with disease recurrence |
| 投稿时间：2024-07-04 修订日期：2024-10-31 |
| DOI：10.11752/j.kqcl.2025.03.06 |
| 中文关键词: 复发性口腔溃疡 复发 可溶性B7-H3 干扰素调节因子5 |
| 英文关键词:Recurrent oral ulcer Recurrence Soluble B7-H3 Interferon regulatory factor 5 |
| 基金项目:四川省卫生健康委员会科研课题(19PJ007) |
|
| 摘要点击次数: 314 |
| 全文下载次数: 72 |
| 中文摘要: |
| 目的 探讨复发性口腔溃疡（ROU）患儿血清可溶性 B7-H3（sB7-H3）和干扰素调节因子 5（IRF5）水平的变化及其与复发的关系。方法 前瞻性选取本院于2021年5月~2023年4月收治的94例ROU患儿作为ROU组，另选同期无口腔溃疡健康儿童97例为对照组。酶联免疫吸附试验（ELISA）检测血清sB7-H3、IRF5 以及唾液中肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平。Pearson 法分析 ROU 患儿血清sB7-H3、IRF5水平与炎性及免疫指标的相关性。多因素Logistic回归法分析ROU患儿复发的影响因素；受试者工作特征（ROC）分析血清 sB7-H3、IRF5 水平对 ROU 患儿复发的预测价值。结果 ROU 组血清 sB7-H3（[8.54±2.42）ng/mL vs（20.71±5.50）ng/mL]及IRF5（[24.82±5.93）pg/mL vs（46.35±8.49）pg/mL]水平均显著低于对照组（P＜0.05），ROU 再复发组治疗后血清 sB7-H3（[10.26±3.09）ng/mL vs（15.45±3.31）ng/mL]及 IRF5（[28.12±6.51）pg/mL vs（37.95±7.15）pg/mL]水平均明显低于 ROU 未再复发组（P＜0.05）。ROU 患儿血清sB7-H3、IRF5 水平均与 TNF-α（r =-0.426、-0.517）、IL-6（r =-0.531、-0.498）呈一定的负相关（P＜0.05），与CD4+（r =0.549、0.443）、CD4+/CD8+（r =0.475、0.504）呈一定的正相关（P＜0.05）。sB7-H3、IRF5、CD4+、CD4+/CD8+为 ROU 患儿复发的保护因素（P＜0.05）。血清 sB7-H3 和 IRF5 水平联合预测 ROU 患儿复发的 AUC（0.893）显著大于两者分别单独预测的AUC。结论 血清sB7-H3和IRF5的水平与ROU复发有关，两者联合对ROU复发具有较高的预测价值。 |
| 英文摘要: |
| Objective To explore the changes in serum soluble B7-H3 (sB7-H3) and interferon regulatory factor 5 (IRF5) in children with recurrent oral ulcers (ROU), and to assess their association with disease recurrence. Methods A total of 94 children with ROU admitted between May 2021 and April 2023 were included as the ROU group, while 97 healthy children served as controls. Serum levels of sB7-H3, IRF5, TNF-α, and IL-6 were measured using enzyme-linked immunosorbent assay (ELISA). Pearson correlation was used to analyze the relationship between sB7-H3, IRF5 and inflammatory or immune indicators. Multivariate logistic regression was employed to identify factors associated with recurrence, and receiver operating characteristic (ROC) curves were utilized to assess the predictive value. Results Serum sB7-H3 (8.54±2.42 ng/mL vs 20.71±5.50 ng/mL) and IRF5 (24.82±5.93 pg/mL vs 46.35±8.49 pg/mL) levels were significantly lower in the ROU group compared to controls (P < 0.05). In the recurrent group, post-treatment levels of sB7-H3 (10.26±3.09 ng/mL) and IRF5 (28.12±6.51 pg/ mL) were significantly lower than in the non-recurrent subgroup (P < 0.05). Both markers showed negative correlations with TNF-α and IL-6, and positive correlations with CD4+ and CD4+/CD8+ ratios (P < 0.05). sB7-H3, IRF5, CD4+, and CD4+/CD8+ were protective against recurrence. The combined AUC for predicting recurrence using sB7- H3 and IRF5 was 0.893, exceeding the predictive value of either marker alone. Conclusion Lower serum levels of sB7-H3 and IRF5 are associated with ROU recurrence, and their combined assessment offers high predictive value for identifying recurrence risk. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |