| 艾娟,王巧云.血清高迁移率族蛋白B1和干扰素-γ变化与牙髓炎根管治疗术后疼痛及生存质量的相关性分析[J].口腔材料器械杂志,2025,34(3):169-173. |
| 血清高迁移率族蛋白B1和干扰素-γ变化与牙髓炎根管治疗术后疼痛及生存质量的相关性分析 |
| Correlation analysis of serum high mobility group protein B1 and interferon-γ with postoperative pain and quality of life after following root canal therapy for pulpitis |
| 投稿时间：2024-04-19 修订日期：2025-03-06 |
| DOI：10.11752/j.kqcl.2025.03.08 |
| 中文关键词: 高迁移率族蛋白B1 干扰素-γ 牙髓炎 根管治疗 相关性分析 |
| 英文关键词:High mobility group protein B1 Interferon-γ Pulpitis Root canal therapy Correlation Analysis |
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| 中文摘要: |
| 目的 探讨高迁移率族蛋白B1（HMGB1）和干扰素-γ（IFN-γ）在牙髓炎患者血清中的变化以及与牙髓炎根管治疗术后疼痛及生存质量的相关性。方法 收集本院牙髓炎治疗的 196例患者（牙髓炎组）。同期另选取健康体检者196例作为对照组。分别在治疗前、治疗后7 d、30 d，采用视觉模拟评分量表（VAS）对患者的疼痛情况进行评分；采集治疗前和治疗后7 d时的血清，分析治疗后7 d血清HMGB1和IFN-γ水平分别与疼痛程度、生存质量的相关性；利用工作特征曲线（ROC）曲线分析其对患者生存质量的预测价值。结果与对照组相比，治疗前牙髓炎组血清HMGB1和IFN-γ显著升高（P＜0.05）。与治疗前相比，牙髓炎组治疗后7 d、30 d的VAS评分显著降低（P＜0.05），与治疗后7 d相比，治疗后30 d的VAS评分显著降低（P＜0.05）。治疗后 7 d血清 HMGB1和 IFN-γ水平与治疗后疼痛均呈一定的正相关（r =0.469，r =0.524，P<0.001），与生存质量均呈负相关（r =-0.563，r =-0.609，P<0.001）。治疗后 7 d 血清 HMGB1、IFN-γ两者联合预测牙髓炎患者生存质量的曲线下面积为 0.869，优于各自单独预测（Z两者联合-HMGB1=4.522、Z两者联合-IFN-γ=3.459，均 P<0.001）。结论 牙髓炎患者根管治疗后血清 HMGB1和 IFN-γ水平与治疗后疼痛呈一定的正相关，与生存质量呈负相关，两者联合对预测牙髓炎术后生存质量有较好的参考价值。 |
| 英文摘要: |
| Objective To investigate the changes of high mobility group protein B1 (HMGB1) and interferon-γ (IFN-γ) in the serum of patients with pulpitis, and their correlation with postoperative pain and quality of life after root canal therapy. Methods A total of 196 patients diagnosed with pulpitis (pulpitis group) were enrolled, alongside 196 healthy individuals as the control group. Pain intensity was assessed using the Visual Analogue Scale (VAS) before treatment, and at 7 and 30 days post-treatment. Serum levels of HMGB1 and IFN-γ were measured before treatment and on day 7 post-treatment. The correlations between serum biomarkers and both pain scores and quality of life were analyzed. The predictive value of HMGB1 and IFN-γ levels for postoperative quality of life was evaluated using receiver operating characteristic (ROC) curves. Results Serum HMGB1 and IFN-γ levels were significantly elevated in the pulpitis group compared to the control group (P < 0.05). VAS scores significantly decreased at 7 and 30 days post-treatment (P < 0.05), with further significant reduction observed between day 7 and day 30 (P < 0.05). Serum HMGB1 and IFN- γ levels were positively correlated with pain scores (r =0.469, r = 0.524, P<0.001), and negatively correlated with quality of life (r =-0.563, r =-0.609, P<0.001) on day 7 post-treatment. The AUC of the combination of of serum HMGB1 and IFN-γ in predicting the quality of life in pulpitis patients was 0.869, which was better than their individual predictions superior to either marker alone (Z combination-HMGB1=4.522, Z combination-IFN-γ=3.459, both P<0.001). Conclusion Elevated serum HMGB1 and IFN-γ levels in patients with pulpitis are associated with greater postoperative pain and poorer quality of life after root canal therapy. Combined detection of these biomarkers offers significant predictive value for assessing postoperative outcomes. |
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