| 李想,司慧明,马艳楠.术前血清CCL20和IL-33水平对种植体预后的预测价值[J].口腔材料器械杂志,2025,34(4):215-219. |
| 术前血清CCL20和IL-33水平对种植体预后的预测价值 |
| Predictive value of preoperative serum CCL20 and IL-33 levels for implant prognosis |
| 投稿时间：2024-12-09 修订日期：2025-05-27 |
| DOI：10.11752/j.kqcl.2025.04.04 |
| 中文关键词: CC趋化因子配体20 白细胞介素33 牙列缺失 口腔种植修复术 预后 预测价值 |
| 英文关键词:CCL20 Interleukin-33 Dental arch loss Oral implant restoration Prognosis Predictive value |
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| 中文摘要: |
| 目的 探讨牙列缺失患者种植前血清CC趋化因子配体20(CCL20)和白细胞介素33(IL-33)变化对种植体预后的预测价值。方法 选择92例牙列缺失患者，根据随访期间情况分为预后良好组（n=57）和预后不良组（n=35）；同时选取90例体检确认无相关疾病的健康志愿者作为对照组。ELISA检测术前各组血清CCL20和IL-33水平；Pearson相关性分析血清CCL20和IL-33水平之间的相关性；Logistic回归模型分析影响术后种植体预后的关键因素；受试者工作特征（ROC）曲线评估术前血清CCL20、IL-33水平在术后种植体预后方面的预测价值。结果 研究组患者血清CCL20水平显著高于对照组，IL-33水平则显著低于对照组（P<0.05）。血清CCL20和IL-33水平之间呈负相关（r=-0.515,P<0.05）。与预后良好组相比，预后不良组患者血清CCL20水平显著升高，IL-33水平则显著下降（P<0.05）。CCL20水平升高是影响种植体预后不良的危险因素，而IL-33水平升高则为预后不良的保护因素（P<0.05）。CCL20和IL-33预测种植体预后的AUC分别为0.813(95%CI:0.718～0.886)和0.827(95%CI:0.734～0.898)；两者联合预测的AUC为0.912(95%CI:0.834～0.961)，优于两者单独检测。结论 术前血清CCL20水平上升和IL-33水平下降与种植体预后紧密相关，两者联合检测对种植体预后的预测效能更高。 |
| 英文摘要: |
| Objective To evaluate the predictive value of preoperative serum CC chemokine ligand 20（CCL20） and interleukin-33（IL-33） levels in determining implant prognosis among edentulous patients. Methods Ninety-two patients with missing dentition who underwent oral implant restoration between May 2021 and January 2024 were prospectively enrolled and categorized into a good-prognosis group（n=57） and a poor-prognosis group（n=35） based on follow-up outcomes. Ninety healthy individuals were recruited as controls. Serum CCL20 and IL-33 levels were quantified by enzyme-linked immunosorbent assay（ELISA）. Correlation between the two cytokines was analyzed by Pearson correlation, while logistic regression identified independent factors affecting implant prognosis. Receiver operating characteristic（ROC） curves were used to assess their predictive efficacy. Results Compared with controls, patients exhibited significantly higher serum CCL20 and lower IL-33 levels（P＜0.05）, which were negatively correlated（r=-0.515, P＜0.05）. The poor-prognosis group showed markedly elevated CCL20 and reduced IL-33 levels compared with the good-prognosis group（P＜0.05）. Elevated CCL20 was identified as a risk factor for poor prognosis, whereas increased IL-33 served as a protective factor（P＜0.05）. The area under the ROC curve（AUC） for predicting postoperative outcomes was 0.813（95% CI: 0.718-0.886） for CCL20 and 0.827（95% CI: 0.734-0.898） for IL-33; combined detection yielded an AUC of 0.912（95% CI: 0.834-0.961）, superior to either marker alone. Conclusion Elevated preoperative serum CCL20 and decreased IL-33 levels are closely associated with implant prognosis. Combined detection of these two indicators provides higher predictive value. |
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