| 栗旭剑,张少华,江越,刘磊,刘立肖.氧化亚氮/氧吸入麻醉下微创拔除下颌低位阻生智齿的疗效及对相关炎症因子的影响[J].口腔材料器械杂志,2026,35(2):100-104. |
| 氧化亚氮/氧吸入麻醉下微创拔除下颌低位阻生智齿的疗效及对相关炎症因子的影响 |
| Efficacy of minimally invasive extraction of low mandibular impacted third molars under nitrous oxide/oxygen inhalation sedation and its effects on related inflammatory factors |
| 投稿时间：2024-08-06 修订日期：2026-01-19 |
| DOI：10.11752/j.kqcl.2026.02.07 |
| 中文关键词: 下颌低位阻生智齿 氧化亚氮/氧吸入 微创拔牙器械 外周血Th17/Treg |
| 英文关键词:Low mandibular impacted third molar Nitrous oxide/oxygen inhalation Minimally invasive extraction instruments Peripheral blood Th17/Treg |
| 基金项目:河北省2024年度医学科学研究课题计划（20240256） |
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| 中文摘要: |
| 目的 探究氧化亚氮/氧吸入麻醉下微创拔除患者下颌低位阻生智齿的疗效及对血清炎症因子及外周血Th17/Treg的影响。方法 选取本院于2022年2月至2024年2月收治的下颌低位阻生智齿的患者88例，随机分为对照组与观察组，各44例。比较两组患者临床疗效、手术情况、外周血Th17/Treg、抗牙龈叶琳菌抗体（PgIgG）肿瘤坏死因子-α（TNF-α）和五聚素3（PTX3）、血清细胞间黏附分子-1（ICAM-1）、前列腺素E2（PGE2）、疼痛程度以及术后并发症。结果 治疗后观察组的手术时间（[26.71±3.62）min]和术中出血量（[7.14±2.11）mL]与对照组（[32.61±5.14）min、（11.05±2.18）mL]相比显著降低（P<0.05）；治疗后观察组的视觉模拟评分值（1.75±0.42）和Th17/Treg（0.33±0.03）低于对照组（[2.66±0.71）分、（0.36±0.04）（]P<0.05）；两组患者治疗后的抗PgIgG、TNF-α和PTX3、ICAM-1、PGE2升高，但观察组低于对照组（P<0.05）；观察组术后并发症发生率低于对照组（P<0.05）。观察组的满意率高于对照组（P<0.05）。结论 氧化亚氮/氧吸入舒适化技术治疗下颌低位阻生智齿患者在改善围术期指标，抑制炎症反应，缓解疼痛等方面优于麻醉剂麻醉治疗，综合疗效显著且并发症显著降低。 |
| 英文摘要: |
| Objective To investigate the efficacy of minimally invasive extraction of low mandibular impacted third molars under nitrous oxide/oxygen inhalation sedation and its effects on serum inflammatory factors and peripheral blood Th17/Treg. Methods A total of 88 patients with low mandibular impacted third molars were enrolled and randomly assigned to a control group and an observation group, with 44 patients in each group. Clinical efficacy, surgical variables, peripheral blood Th17/Treg, levels of anti-Porphyromonas gingivalis IgG antibody (PgIgG), tumor necrosis factor-α (TNF-α), pentraxin 3 (PTX3), intercellular adhesion molecule-1 (ICAM-1), prostaglandin E2 (PGE2), pain severity, and postoperative complications were compared between the two groups. Results After treatment, the operation time and intraoperative blood loss in the observation group were significantly lower than those in the control group ([26.71±3.62] min vs [32.61±5.14] min; [7.14±2.11] mL vs [11.05±2.18] mL; both P<0.05). The visual analogue scale score and Th17/Treg ratio in the observation group were also lower than those in the control group (1.75±0.42 vs 2.66±0.71; 0.33±0.03 vs 0.36±0.04; both P<0.05). Levels of PgIgG, TNF-α, PTX3, ICAM-1, and PGE2 increased after treatment in both groups, with lower levels observed in the observation group than in the control group (P<0.05). The incidence of postoperative complications was lower in the observation group than in the control group (P<0.05), whereas the satisfaction rate was higher in the observation group (P<0.05). Conclusion For patients with low mandibular impacted third molars, minimally invasive extraction under nitrous oxide/oxygen inhalation sedation was superior to conventional anesthetic management in improving perioperative indicators, suppressing inflammatory responses, and relieving pain, with better overall efficacy and fewer postoperative complications. |
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