| 宋小顺,王振宇,李学智.血清CTRP3、PCSK9水平与口腔种植修复术预后的相关性[J].口腔材料器械杂志,2026,35(3):160-164. |
| 血清CTRP3、PCSK9水平与口腔种植修复术预后的相关性 |
| Correlation Between Serum CTRP3 and PCSK9 Levels and the Prognosis of Dental Implant Restoration |
| 投稿时间：2024-12-24 修订日期：2025-06-09 |
| DOI：10.11752/j.kqcl.2026.03.06 |
| 中文关键词: 肿瘤坏死因子相关蛋白3 前蛋白转化酶枯草溶菌素9 口腔种植修复术 种植体 相关性 |
| 英文关键词:Tumor necrosis factor related protein 3 Proprotein convertase subtilisin/kexin type 9 Oral implant restoration surgery Implant Correlation |
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| 中文摘要: |
| 目的 探究血清肿瘤坏死因子相关蛋白3(CTRP3)、前蛋白转化酶枯草溶菌素9(PCSK9)表达水平与口腔种植修复术预后的关系。方法 选取2022年2月至2024年4月在我院接诊的100例口腔种植修复术患者，另选60例同期体检的口腔健康者作为健康组。术前1周、术后1周和术后1个月取血，用ELISA法分析血清CTRP3、PCSK9水平以及CRP、UDPd/Scr比值、IL-1、TNF-α水平；术后1个月，根据X线结果分组，分为结合不良组（n=20）和结合良好组（n=80）。多因素Logistic分析术后结合效果的影响因素。结果 术前1周，研究组血清各指标水平与健康组的差异不显著（P>0.05）；术后1周和1个月，与健康组相比，研究组血清PCSK9水平及CRP、UDPd/Scr、IL-1、TNF-α的水平均升高，CTRP3水平降低（P<0.05）；术前1周、术后1周和1个月，血清CTRP3与PCSK9、CRP、UDPd/Scr、IL-1、TNF-α均呈负相关（P<0.05），血清PCSK9与CRP、UDPd/Scr、IL-1、TNF-α均呈正相关（P<0.05）；与结合良好组相比，结合不良组血清PCSK9、CRP、UDPd/Scr、IL-1、TNF-α水平均升高，血清CTRP3水平降低（P<0.05）。血清CTRP3、PCSK9、CRP、UDPd、Scr、IL-1、TNF-α为影响种植体预后的因素（P<0.05）。结论 血清PCSK9水平在口腔种植修复术患者中明显升高，而CTRP3水平明显降低，为术后结合效果及预后的相关影响因素。 |
| 英文摘要: |
| Objective To explore the correlation between serum tumor necrosis factor-related protein 3(CTRP3) and proprotein convertase subtilisin/kexin type 9(PCSK9) with prognosis of implant in patients undergoing oral implant restoration surgery. Methods A total of 100 patients who underwent oral implant restoration surgery in our hospital from February 2022 to April 2024 were selected. Meanwhile, another 60 orally healthy individuals who experienced physical check-ups were selected as the healthy group. One month after surgery, X-ray examination was performed on all patients, and they were separated into the poor integration group(20 cases) and the good integration group(80 cases) based on the examination results. The ELISA method was used to analyze the levels of serum CTRP3 and PCSK9. An automatic biochemical analyzer was used to detect serum inflammatory factors. Multivariate logistic regression was applied to analyze the factors that affected the postoperative integration effect. Results At 1 week before surgery, serum CTRP3, PCSK9 levels, CRP, UDPd/Scr ratio, IL-1 and TNF-α levels in the study group were not significantly different from those in the healthy group(P>0.05); Serum CTRP3 was negatively correlated with PCSK9, CRP, UDPd/Scr, IL-1 and TNF-α at 1 week before surgery and 1 week and 1 month after surgery(P<0.05). Serum PCSK9 was positively correlated with CRP, UDPd/Scr, IL-1 and TNF-α(P<0.05). Compared with the good integration group, the serum PCSK9, CRP, UDPd/Scr, IL-1 and TNF-α levels in the poor integration group were increased, and the serum CTRP3 level was decreased(P<0.05). Serum CTRP3, PCSK9, CRP, UDPd/Scr, IL-1 and TNF-α were all factors affecting the prognosis of implants(P<0.05). Conclusion Serum PCSK9 level is significantly increased, while CTRP3 level is significantly decreased in patients with oral implant restoration, which is a related factor for postoperative combination effect and prognosis. |
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