| 白琴,刘艳春,赵文,李星茹.PRF联合iRoot BP Plus在显微根尖手术治疗难治性根尖周炎的应用效果[J].口腔材料器械杂志,2026,35(3):184-187. |
| PRF联合iRoot BP Plus在显微根尖手术治疗难治性根尖周炎的应用效果 |
| The Effect of PRF Combined with iRoot BP Plus in Endodontic Microsurgery for Refractory Periapical Periodontitis |
| 投稿时间：2024-12-23 修订日期：2025-04-07 |
| DOI：10.11752/j.kqcl.2026.03.11 |
| 中文关键词: 难治性根尖周炎 富血小板纤维蛋白 显微根尖手术 iRoot BP Plus |
| 英文关键词:Refractory Periapical Inflammation Platelet Rich Fibrin Endodontic Microsurgery iRoot BP Plus |
| 基金项目:陕西省教育厅专项科研计划项目(21JK0452) |
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| 中文摘要: |
| 目的 探究富血小板纤维蛋白（PRF）联合iRoot BP Plus在显微根尖手术治疗难治性根尖周炎（RAP）的应用效果。方法 选取96例RAP患者，随机分为2组，各48例，均行显微根尖手术。观察组57颗患牙行iRoot BP Plus倒充填后覆盖PRF膜，对照组55颗患牙行iRoot BP Plus倒充填。观察两组治疗效果，检测患者龈沟液炎症因子水平，评估患者术后疼痛情况及患牙修复效果。结果 对照组、观察组治疗成功率差异无统计学意义（85.45%vs. 89.47%,P>0.05）；观察组术后龈沟液超敏C反应蛋白（hs-CRP）、白细胞介素-1β(IL-1β)及肿瘤坏死因子α(TNF-α)水平均低于对照组（P<0.05）。观察组术后24 h、48 h及术后1周疼痛视觉模拟（VAS）评分低于对照组（P<0.05）。术后6、12个月观察组根尖周指数（PAI）均低于对照组（P<0.05）。结论 PRF联合iRoot BP Plus能够减轻RAP患者显微根尖手术的术后炎症反应，缓解术后疼痛，促进根尖周骨组织修复。 |
| 英文摘要: |
| Objective To investigate the effect of platelet-rich fibrin(PRF) combined with iRoot BP Plus in the treatment of refractory periapical periodontitis(RAP). Methods A total of 96 RAP patients were randomly divided into 2 groups, 48 cases in each group, all of which underwent endodontic microsurgery. In the observation group, 57 affected teeth received retrograde filling with iRoot BP Plus followed by coverage with PRF membrane. In the control group, 55 affected teeth were treated with iRoot BP Plus retrograde filling alone. The therapeutic effects of the two groups were observed, the levels of gingival crevicular fluid inflammatory factors were detected, and the postoperative pain and restoration effects of the affected teeth were evaluated. Results There was no significant difference in the treatment success rate between the control group and the observation group(85.45% vs. 89.47%, P>0.05). The levels of C-reactive protein(hs-CRP), interleukin-1β(IL-1β), and tumor necrosis factor α(TNF-α) in gingival crevicular fluid of the observation group were lower than those of the control group(P<0.05). The visual analogue scale(VAS) scores of the observation group at 24 h, 48 h, and 1 week after surgery were lower than those of the control group(P<0.05). The Periapical Index(PAI) in the observation group was lower than that in the control group at 6 and 12 months postoperatively(P<0.05). Conclusion PRF combined with iRoot BP Plus can reduce inflammation, relieve postoperative pain, and promote periapical bone tissue repair in RAP patients. |
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