| 赵向,段娇红.镁基金属对粪肠球菌的体外抑制作用[J].口腔材料器械杂志,2016,25(3):139-143. |
| 镁基金属对粪肠球菌的体外抑制作用 |
| In vitro effects of Mg-based metals on enterococus faecalis in root canal model |
| 投稿时间：2015-07-21 修订日期：2016-04-09 |
| DOI：10.11752/j.kqcl.2016.03.06 |
| 中文关键词: 纯镁 镁铜合金 氢氧化钙 抑菌 粪肠球菌 |
| 英文关键词:Magnesium Mg-Cu alloys Calcium hydroxide Bacteriosasis Enterococcus faecalis |
| 基金项目:辽宁省博士启动基金（编号：201501027） |
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| 中文摘要: |
| 目的 评价纯镁和镁铜合金对粪肠球菌的体外抗菌效果。方法 选取因正畸新鲜拔除的人的单根管下颌前磨牙40颗，随机分为4组，每组10颗牙。所有牙齿清理根管后灭菌，建立粪肠球菌感染根管模型。每组分别用以无菌生理盐水为赋形剂调制的氢氧化钙糊剂（A组）、镁粉糊剂（B组）、镁铜合金粉糊剂（C组）、生理盐水（D组）进行根管封药7天。封药前后分别取样，接种在普通营养琼脂平板上培养，计数菌落。结果 封药前4组根管内细菌量的差异无统计学意义（P>0.05）。D组封药前后根管内细菌量无统计学差异（P>0.05）。A、B、C 3组封药后根管内细菌量均明显减少，与封药前细菌量比较，差异具有统计学意义（P<0.05）。A、B、C 3组间两两比较，封药后根管内细菌减少量差异无统计学意义（P>0.05）。结论 纯镁和镁铜合金对粪肠球菌均有一定的抗菌效果。但各组根管内仍有粪肠球菌残留，关于镁和镁铜合金在口腔临床医学中的应用价值还需要进一步研究。 |
| 英文摘要: |
| Objective To evaluate the antibacterial efficacy of pure magnesium (Mg) and Mg-Cu alloys using anin vitro model infected by Enterococcus Faecalis(Efaecalis). Methods Forty freshly extracted human single-rooted mandibular premolars were collected and divided randomly into 4 groups, with 10 teeth in each group . After cleaning and sterilization, the root canals were infected with E． faecalis to establish the E． faecalis infected models. All root canals were dressed for 7 days with different intracanal medicament as follows: group A with calcium hydroxide paste plus sterile normalsaline; group B with magnesium (Mg) paste plus sterile normalsaline; group C with Mg-Cu alloys paste plus sterile normal saline; group D with sterile normal saline. Microbiological samples were collected from root canal before and after dressing, and were incubated at 37℃ and plated onto common nutrient agar .The colony of bacteria was counted (CFU/ml). Results There was no statistically significant difference in the number of E． faecalis of all groups before root canal dressings (P>0.05). After dressing, no significant difference was observed in the number of E.faecalis in the group D (P>0.05). The number of E． faecalis in group of calcium hydroxide, Mg and Mg-Cu alloys were effectively reduced (P<0.05). While there was no signifi-cant difference between every two groups of Group A,B and C (P>0.05). Conclusion The results suggested that Mg and Mg-Cu alloys paste plus sterile physiological saline were all effective for eliminating E． faecalis in root canal specimens. Further studies are needed to confirm the value of Mg and Mg-Cu alloys in clinical treatment. |
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